development of new african horsesickness cell culture killed vaccines

Development of new African horsesickness cell culture killed vaccines

African Horse-Sickness Live and Killed Virus Tissue Culture Vaccine

Protein aggregation complicates the development of baculovirus-expressed African horsesickness virus serotype 5 VP2 subunit vaccines.

This paper describes the expression of a cloned African horsesickness virus (AHSV) serotype 5 VP2-gene by a baculovirus recombinant that was generated by the BAC-TO-BAC system. Immunization of horses with crude cell lysates containing recombinant baculovirus-expressed AHSV5 VP2 did induce neutralizing antibodies, but afforded only partial protection against virulent virus challenge. Further ana...

Preparation and characterization of a soluble precipitating antigen from African horsesickness virus propagated in cell cultures

african horse-sickness live and killed virus tissue culture vaccine

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Recent Advances in Immunization of Horses Against African Horsesickness